According to UNAIDS, key populations and their sexual partners accounted for approximately 49 percent of new HIV infections globally in 2024. In sub-Saharan Africa, these groups contributed about a quarter of all new infections, underscoring the critical need to prioritize prevention for these communities. 

The Power of Prevention project strengthens national efforts to put HIV prevention at the forefront of political and funding agendas. It mobilizes key population-led organizations in Malawi, South Africa and Zimbabwe to advocate for sustainable long-term financing for cost effective prevention tools, such as long-acting pre-exposure prophylaxis (LA-PrEP), and also advances policies to ensure key populations’ access to essential HIV prevention services. The project is supported by the Gates Foundation.