This report assesses the macroeconomic consequences of the current Ebola outbreak in the Democratic Republic of the Congo and its potential spillover effects across Africa. Using a multi-country Computable General Equilibrium (CGE) model, it simulates three progressively complex scenarios: a contained outbreak affecting the DRC and Uganda, wider regional economic spillovers, and a broader polycrisis combining the outbreak with global geopolitical shocks. The analysis quantifies impacts on growth, employment, trade, investment, and public finances, providing evidence on how health emergencies can trigger far-reaching economic disruption and offering policymakers insights to strengthen preparedness, resilience, and coordinated regional response.