Women play a critical role in Ghana’s economy, particularly in agriculture, vocational trade and entrepreneurship. However, structural barriers such as limited access to land, financial services, and vocational training hinder their ability to fully participate in economic activities. This study assesses the forms and levels of women’s livelihoods in the Lambussie and West Gonja Districts with a focus on vocational and entrepreneurial engagement. It also explores the key challenges and identifies opportunities to enhance women’s economic empowerment.